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Dianova DIA-H09-M說明書
Art.-Nr.
DIA-H09
特異性
IDH1 R132H
物種反應(yīng)性
人的
寄主物種
老鼠
同型
的IgG2a
克隆
H09
克隆性（單克隆/多克?。?/span>
單克隆
應(yīng)用
免疫組化（石蠟包埋切片）
Western Blot
免疫組化（IHC）
稀釋
組織/細(xì)胞化學(xué)1:20
格式
純化的凍干抗體（來自培養(yǎng)上清液）
產(chǎn)品系列/主題
腫瘤標(biāo)志物/生物學(xué)
神經(jīng)生物學(xué)
有可能的使用
用于體外診斷用途
溫度 - 儲存
2-8℃
搜索代碼
DIAH09
IHC，F(xiàn)FPE，石蠟
制造商/品牌
dianova
抗IDH1 R132H抗體克隆H09（由dianova授權(quán)給德國癌癥研究中心）提供不同的CE IVD標(biāo)記格式：
目錄號 | 產(chǎn)品 | 形成 | 狀態(tài) | 數(shù)量 | 價錢 |
DIA-H09 | 抗IDH1 R132H，克隆H09 | 濃縮，凍干 | CE IVD | 500μl | 482,00€ |
DIA-H09-M | 抗IDH1 R132H，克隆H09 | 濃縮，凍干 | CE IVD | 100μl | 142,00€ |
MAD-000475QD-3 | 抗IDH1 R132H，克隆H12 | 預(yù)先稀釋，即用型 | CE IVD | 3毫升 | 264,00€ |
MAD-000475QD-7 | 抗IDH1 R132H，克隆H15 | 預(yù)先稀釋，即用型 | CE IVD | 7毫升 | 482,00€ |
MAD-000475QD-12 | 抗IDH1 R132H，克隆H18 | 預(yù)先稀釋，即用型 | CE IVD | 12毫升 | 826,00€ |
福爾馬林固定石蠟包埋的腦組織切片中人IDH1 R132H的免疫組織化學(xué)
A：IDH1突變特異性抗體克隆H09在間變性少突細(xì)胞瘤的腫瘤中心的強烈反應(yīng)。
B：間變性星形細(xì)胞瘤的浸潤區(qū)，通過抗體克隆H09特異性標(biāo)記浸潤性神經(jīng)膠質(zhì)瘤細(xì)胞。
C：用抗體克隆H09鑒定遠(yuǎn)離腫瘤中心的白質(zhì)中的單個腫瘤細(xì)胞。
D：由少突神經(jīng)膠質(zhì)瘤浸潤的皮質(zhì)，具有抗體克隆H09對腫瘤細(xì)胞的特異性標(biāo)記。
E：GFAP（膠質(zhì)原纖維酸性蛋白，紅色）和少突膠質(zhì)細(xì)胞瘤浸潤區(qū)的H09（棕色）的雙重染色，證明腫瘤細(xì)胞的特異性標(biāo)記但不是GFAP陽性反應(yīng)性星形膠質(zhì)細(xì)胞的特異性標(biāo)記。
F：抗體克隆H09與IDH1 R132H突變的彌漫性星形細(xì)胞瘤（左）的強烈反應(yīng)，但不與野生型腫瘤（右）反應(yīng)。
（圖片由德國海德堡大學(xué)海德堡大學(xué)神經(jīng)病理學(xué)系/
德國癌癥研究中心（DKFZ）臨床合作單位神經(jīng)病理學(xué)系醫(yī)學(xué)博士Andreas von Deimling提供）
背景
抗體克隆 H09與福爾馬林固定腦腫瘤組織切片中異檸檬酸脫氫酶1 （IDH1）R132H點突變特異性反應(yīng)。IDH1密碼子132的雜合點突變在世界衛(wèi)生組織（WHO）II級和III級神經(jīng)膠質(zhì)瘤中很常見。IDH1 R132H突變發(fā)生在大約70％的星形細(xì)胞瘤和少突神經(jīng)膠質(zhì)瘤中。IDH1 R132H突變在特定腦腫瘤實體中的高頻率和分布允許通過免疫組織化學(xué)對各種腫瘤的高度敏感和特異性區(qū)分，例如來自原發(fā)性膠質(zhì)母細(xì)胞瘤的間變性星形細(xì)胞瘤或來自毛細(xì)胞星形細(xì)胞瘤或室管膜瘤的彌散性星形細(xì)胞瘤WHO II級。值得注意的是，從反應(yīng)性神經(jīng)膠質(zhì)增生中識別具有IDH1突變的腫瘤的浸潤邊緣。
ATRX（dianova clone AX1）和IDH1R132H（dianova clone H09）的組合免疫組織化學(xué)
取代了分子檢測。
用于診斷星形細(xì)胞瘤和少突神經(jīng)膠質(zhì)瘤的常規(guī)實用方法開始于針對IDH1 R132H和ATRX表達(dá)的進行IHC 。用ATRX和IDH1 R132H的初始IHC逐步分析分子參數(shù)，然后進行1p / 19q分析，然后通過IDH測序，顯著減少了明確診斷所需的分子檢測次數(shù)（Reuss等，2015）。
比較研究
參考
SKU | Product Name | Quantity | Price |
DIA-H09 | Anti-IDH1 R132H (Hu) from Mouse (Clone: H09) | 500 µl | 482,00 € plus VAT
Free shipping inside Germany |
DIA-H09-L | Anti-IDH1 R132H (Hu) from Mouse (Clone: H09) - prediluted RTU | 8 ml | 482,00 € plus VAT
Free shipping inside Germany |
DIA-H09-M | Anti-IDH1 R132H (Hu) from Mouse (Clone: H09) | 0,1 ml | 142,00 € plus VAT |
Dianova2019年產(chǎn)品價格表
貨號 | 品名 | 規(guī)格 | 價格 | 品牌 |
DIA-100 | Anti-Fibroblasten (CD90) (Hu) from Mouse (Clone: AS02) | 200µg | 4680 | dianova |
DIA-100-M | Anti-Fibroblasten (CD90) (Hu) from Mouse (Clone: AS02) | 20µg | 0 | dianova |
DIA-120 | Anti-Fibroblasten (CD90) (Hu) from Mouse (Clone: AS02) -FITC | 100test | 5360 | dianova |
DIA-530-P05 | Anti-p53 (Hu) from Mouse (Clone: CC53) | 0.5ml | 4780 | dianova |
DIA-530-M | Anti-p53 (Hu) from Mouse (Clone: CC53) | 0.1ml | 0 | dianova |
DIA-670-P05 | Anti-Ki-67/MIB1 (Hu) from Mouse (Clone: Ki-67P) CE-IVD | 0.5ml | 4780 | dianova |
DIA-670-P1 | Anti-Ki-67/MIB1 (Hu) from Mouse (Clone: Ki-67P) CE-IVD | 1ml | 6500 | dianova |
DIA-670-M | Anti-Ki-67/MIB1 (Hu) from Mouse (Clone: Ki-67P) CE-IVD | 0.1ml | 0 | dianova |
DIA-700-P05 | Anti-GFAP (Hu) from Mouse (Clone: IF3) CE-IVD | 0.5ml | 4780 | dianova |
DIA-700-M | Anti-GFAP (Hu) from Mouse (Clone: IF3) CE-IVD | 0.5ml | 0 | dianova |
DIA-AX1 | Anti-ATRX (Hu) from Mouse (Clone: AX1) | 0.5ml | 6760 | dianova |
DIA-CAL-100 | Anti-CALRETICULIN mutation (Hu) from Mouse (Clone CAL2) | 0.1ml | 5960 | dianova |
DIA-CAL-250 | Anti-CALRETICULIN mutation (Hu) from Mouse (Clone CAL2) | 0.25ml | 13960 | dianova |
DIA-H09 | Anti-IDH1 R132H (Hu) from Mouse (Clone: H09) CE-IVD | 0.5ml | 9640 | dianova |
DIA-H09-M | Anti-IDH1 R132H (Hu) from Mouse (Clone: H09) CE-IVD | 0.1ml | 2840 | dianova |
DIA-H09-L | Anti-IDH1 R132H (Hu) from Mouse (Clone: H09), prediluted, ready-to-use | 8ml | 9640 | dianova |
DIA-W09 | Anti-IDH1 (Hu) from Rat (Clone: W09) | 0.5ml | 4960 | dianova |
DIA-TG1 | Anti-TIGIT (Hu) from Mouse (Clone TG1) | 0.5ml | 20400 | dianova |
DIA-TG1-M | Anti-TIGIT (Hu) from Mouse (Clone TG1) | 0.1ml | 5720 | dianova |
DIA-TC8 | Anti-CD8 (Hu) from Mouse (Clone TC8 ) | 0.5ml | 9200 | dianova |
DIA-P16-OD | Anti-P16 (Hu) from Mouse (Clone JAP16) | 0.1ml | 7360 | dianova |
DIA-303 | Anti-CD3 (Ms, FFPE) from Rat (Clone: HH3E) | 0.5ml | 6900 | dianova |
DIA-310 | Anti-CD31 (Ms, FFPE) from Rat (Clone: SZ31) | 0.5ml | 8040 | dianova |
DIA-404 | Anti-CD4 (Ms, FFPE) from Rat (Clone GHH8) | 0.2ml | 6900 | dianova |
DIA-808 | Anti-CD8a (Ms, FFPE) from Rat (Clone GHH8) | 0.2ml | 6900 | dianova |
DIA-60 | Anti-FasL, soluble (Hu) from Mouse (Clone: 94) | 1ml | 4760 | dianova |
DIA-900-100 | Anti-HIS-Tag (affinity 3x 10‐10M (Biacore™) from Mouse (Clone: 13/45/31) | 100µg | 2960 | dianova |
DIA-900-200 | Anti-HIS Epitope-Tag (affinity 3x 10‐10M (Biacore™) from Mouse (Clone: 13/45/31) | 200µg | 5160 | dianova |
DIA-900-FITC | Anti-HIS Epitope-Tag (affinity 3x 10‐10M (Biacore™) from Mouse (Clone:13/45/31) -FITC | 1ml | 5960 | dianova |
DIA-900-BIOT | Anti-HIS Epitope-Tag (affinity 3x 10‐10M (Biacore™) from Mouse (Clone:13/45/31) -Biotin | 100µg | 3960 | dianova |
DIA-910-200-ABF | Anti-HIS Epitope-Tag (affinity 3x 10‐10M (Biacore™) from Mouse (Clone:13/45/31) Acid/BSA-free | 200µg | 4960 | dianova |
DIA.910-1MG-ABF | Anti-HIS Epitope-Tag (affinity 3x 10‐10M (Biacore™) from Mouse (Clone:13/45/31) Acid/BSA-free | 1mg | 19840 | dianova |
SCR-028841 | IS Adhesion Slides | 50pcs. | 1620 | dianova |
SCR-028855 | IS Adhesion Slides | 5pcs. | 詢價 | dianova |
SCR-028842 | IS Adhesion Slides | 100pcs. | 2440 | dianova |
SCR-038447 | Immunoselect Antifading Mounting Medium | 15ml | 960 | dianova |
SCR-038587 | Immunoselect Antifading Mounting Medium | 1ml | 詢價 | dianova |
SCR-038448 | Immunoselect Antifading Mounting Medium DAPI | 15ml | 1180 | dianova |
SCR-038588 | Immunoselect Antifading Mounting Medium DAPI | 1ml | 詢價 | dianova |
SCR-038449 | Immunoselect Antifading Mounting Medium PI | 15ml | 1180 | dianova |
SCR-072967 | Immunoselect Mounting Medium without hardener | 15ml | 960 | dianova |
SCR-093035 | Immunoselect Antifading Mounting Medium DAPI without hardener | 15ml | 1180 | dianova |
SCR-093036 | Immunoselect Antifading Mounting Medium PI without hardener | 15ml | 1180 | dianova |
DIA-0302-I | p53-auto antibody ELISA-Kit (Human) CE-IVD | 96test | 10960 | dianova |
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